HAND2 Targets Define a Network of Transcriptional Regulators that Compartmentalize the Early Limb Bud Mesenchyme

Authors: MarcoOsterwalder1DarioSpeziale1MalakShoukry2RajivMohan3RobertIvanek1ManuelKohler4ChristianBeisel4XiaohuiWen5Suzie J.Scales5Vincent M.Christoffels3AxelVisel267JavierLopez-Rios1RolfZeller1;

doi: 10.5281/zenodo.4431849 , 10.5281/zenodo.4431850

HAND2 Targets Define a Network of Transcriptional Regulators that Compartmentalize the Early Limb Bud Mesenchyme

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Abstract

Highlights • ChIP-seq identifies the CRMs bound by endogenous HAND2 in embryos and limb buds • HAND2 controls key transcriptional regulators acting upstream of SHH in limb buds • These transcriptional circuits define proximal, anterior, and posterior identities • HAND2 establishes anterior and posterior compartments by regulating Gli3 and Tbx3

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