Growing demand for customized pharmaceutics and medical devices makes the impact of additive manufacturing increased rapidly in recent years. Three-dimensional printing is a revolutionary technique that uses computer aided design software and programming to create three dimensional ob­jects by placing material on a substrate. 3D printing is an additive layer manufacturing technique, where consecutive layers of material are de­posited or solidified to form a 3D structure. The 3D printing has become one of the most revolutionary and powerful tool serving as a technology of precise manufacturing of individually developed dosage forms, tissue engineering and disease modeling. The current achievements include multifunctional drug delivery systems with accelerated release characteristic, adjustable and personalized dosage forms, implants and phantoms corresponding to specific patient anatomy as well as cell based materials for regenerative medicine. The 3D printing process desires to be espoused by pharmaceutical sector and capable of exploring the marvels fetched by the approach. Key words: Three-dimensional printing, Structure, Pharmaceutics, Medical devices, Tissue engineering.