Introduction: Doctors in hospital practice often face chronic liver disease (CLD). Hepatic encephalopathy is a serious complication of chronic liver disease, most commonly in people with advanced cirrhosis. In patients with stable cirrhosis, hepatic encephalopathy is often followed by easily identifiable triggering events. The aim of the study is to understand the triggering factors and their frequency in CLD patients with hepatic encephalopathy in order to prevent mortality and morbidity. Methods: This descriptive observational study was conducted to identify triggers and their frequency among 50 cases of diagnosed chronic liver disease with hepatic encephalopathy at the Medicine department of Jalalabad Ragib-Rabeya Medical College & Hospital, Bangladesh for one-year duration from March 2019 to March 2020. Results: Among 50 patients, 36 patients (72%) were men, 14 (28%) women. The study found that the incidence of age 14 (28%) was 41 to 50 years, and 08 (16%) 51 to 60 years, 12 (24%)> 60 years. Of the 50 patients, the etiology of cirrhosis was hepatitis B virus in 28 (56%), hepatitis C virus in 4 (8%), both hepatitis B and C in 02 (4%). Among 50 patients 13 (26 %)) were grade 3 and 11 (22%) in grade 2 hepatic encephalopathy. According to Child-Pugh with a score of 16 (32%) in class C and 09 (18%) in class B. The most common triggers were gastrointestinal bleeding (28%), infection (26%), mixed (16%) and unknown (20%). In this study, the mortality rate was 32% of the majority of patients in Child-Pugh Class C. Conclusions: The most common triggers of hepatic encephalopathy in this study were the upper G.I. bleeding, infection, mixed factor and electrolyte imbalance. To prevent hepatic encephalopathy, caution should be exercised in administering diuretics to patients with chronic liver disease. Maintaining early and effective infection control measures and better hygiene conditions in government hospitals are imperative. Key words: precipitating factors, hepatic encephalopathy, chronic liver disease.