The COVID-19 crisis, in which we are currently present, has both momentary and lasting repercussions on the entire system of international relations, leading to geopolitical metamorphoses. Even for this reason and because the new virus has a dynamic evolution in time and space, it is necessary to research the impact of the new virus not only from a biogenetic perspective, but also from the perspective of other domanins, including geopolitics. The events we are attendingtoday are challenges to geopolitical changes around the world. Such as during epidemic over time, the viruses that cause them will change and appear, one thing remains constant: they will always influence not only interpersonal relationships, but will lead new realities in the system of international relations. This article aims to distinguish the main repercussions of the new COVID-19 virus on the system of international relations. Also in this article are highlighted some scenarios that may develop in the post-crisis period COVID-19.