A study of the 70 years of strategic relations between the US and Pakistan reveals that the main consideration in the partnership has always been security. Considering the changes in international politics that have a particular impact in the region-like China's Belt and Road Initiative (BRI) and the growing support for multilateralism-it is high time the two review this relationship and look beyond the security lens. Pakistan, population wise the sixth largest country, sits at the crossroads of major powers' interest due to its pivotal geographic location and natural resources. This study analyses various phases of the US-Pakistan relations in the region. The discussion finds Pakistan is a lynchpin for Central, South and West Asia connecting the East and West. Avoiding Pakistan shall be a gross diplomatic mistake by the US, rather a renewed partnership that thinks beyond the security of this region is required. The focus should on development, social, economic, and environmental challenges to explore opportunities for partnership between the US and Pakistan.