Introduction: Kidney stones are dense masses that form in the kidney when there are increased levels of calcium, oxalate, cystine, or phosphate and very less liquid. Calcium oxalate stones are triggered by too much oxalate in the urine. Oxalate is considered an unusable end product of mammalian metabolism and urinary oxalate is derived from endogenous metabolic sources, primarily produced by the liver. Aims and objectives: The basic aim of the study is to analyze the use of probiotics supplements for the management of calcium oxalate kidney Stone in local population of Pakistan. Methodology of the study: This cross sectional study was conducted at Allied Hospital Faisalabad in April 2019 to July 2019. This was basically a preliminary study which was conducted for the awareness of those patients who are suffering from kidney stones. For this purpose we get permission from the concerned committee of hospital. Results: The use of prebiotics, probiotics, and synbiotics is gradually gaining acceptance in the medical community. There have been multiple claims that they are beneficial in the prevention and treatment of different renal conditions. Unfortunately, clinical evidence to support the safety and efficacy of these supplements is often sparse. Conclusion: It is concluded that some evidence has supported the use of prebiotics, probiotics, or synbiotics, especially for the treatment of diarrhea, their use in other disease states is controversial.