Obese patients with NASH have increased hepatic expression of SARS-CoV-2 critical entry points

Authors: Marcos F. Fondevila1,2,† Maria Mercado-Gómez3,† Amaia Rodríguez2,4,† Maria J. Gonzalez-Rellan1,2,† Paula Iruzubieta5 Víctor Valentí2,4 Javier Escalada2,4 Markus Schwaninger6 Vincent Prevot7 Carlos Dieguez1,2 Javier Crespo5 Gema Frühbeck2,4 Maria L. Martinez-Chantar3,* Ruben Nogueiras1,2;

doi: 10.5281/zenodo.4320876 , 10.5281/zenodo.4320877

Obese patients with NASH have increased hepatic expression of SARS-CoV-2 critical entry points

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Abstract

To the Editor: We read with great interest the article published by Biquard and colleagues showing that, according to public transcriptomic data, the hepatic expression of angiotensin converting enzyme 2 (ACE2) and the cellular transmembrane protease serine 2 (TMPRSS2) remains unchanged in patients with metabolicassociated fatty liver disease (MAFLD).1 SARS-CoV-2 attaches to cells by binding to its receptor ACE2. TMPRSS2 then cleaves the SARS-CoV-2 spike protein, allowing fusion of cellular and viral membranes.2 Despite this retrospective study, there is growing evidence that patients with MAFLD are at higher risk of COVID19 disease progression.3–5

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