The present study was undertaken to enhance solubility and dissolution rate of rosuvastatin by formulating it as a self -micro emulsifying drug delivery system (SMEDDS). The SMEDDS were prepared by using castor oil and sesame oil as oils, Tween 80 as surfactant and PEG 200 as co-surfactant. The prepared SMEDDS were further evaluated for drug content, thermodynamic stability and in vitro drug release. Among all the formulations the drug release for F2 formulation was 99.70% in 120 min. So it was considered as the optimized formulation. The selected optimized F2 formulation was characterized by drug excipient compatibility using FTIR spectroscopy, scanning electron microscopy and globule size. The stability studies indicate that the formulated SMEDDS was stable for 60 days.