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COVID-19 Therapy Target Discovery with Context-Aware Literature Mining

Authors: Martinc, Matej; Škrlj, Blaž; Pirkmajer, Sergej; Lavrač, Nada; Cestnik, Bojan; Marzidovšek, Martin; Pollak, Senja;

COVID-19 Therapy Target Discovery with Context-Aware Literature Mining

Abstract

The abundance of literature related to the widespread COVID19 pandemic is beyond manual inspection of a single expert. Development of systems, capable of automatically processing tens of thousands of scientific publications with the aim to enrich existing empirical evidence with literature-based associations is challenging and relevant. We propose a system for contextualization of empirical expression data by approximating relations between entities, for which representations were learned from one of the largest COVID-19-related literature corpora. In order to exploit a larger scientific context by transfer learning, we propose a novel embedding generation technique that leverages SciBERT language model pretrained on a large multi-domain corpus of scientific publications and fine-tuned for domain adaptation on the CORD-19 dataset. The conducted manual evaluation by the medical expert and the quantitative evaluation based on therapy targets identified in the related work suggest that the proposed method can be successfully employed for COVID-19 therapy target discovery and that it outperforms the baseline FastText method by a large margin.

Keywords

FOS: Computer and information sciences, Contextual embeddings, Computer Science - Computation and Language, COVID-19, Computer Science - Digital Libraries, Representation learning, Computer Science - Information Retrieval, Knowledge discovery, Digital Libraries (cs.DL), Computation and Language (cs.CL), Literature mining, Information Retrieval (cs.IR)

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selected citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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