This study is designed to investigate the inhibitory effect of Celosia trigyna against xanthine oxidase. Total flavonoid, phenol, vitamin C were evaluated using standard methods and inhibitory activity of Celosia trigyna extract on xanthine oxidase (XO) activity in vitro and chelating properties of extract against Iron (II) were also carried out. The results showed that the extract contained high content of flavonoids, phenolic acid and vitamin C that are beneficial to health. The extract inhibited XO in a dose-dependent manner. The extract also chelated Fe2+ in a dose-dependent manner. Celosia trigyna extract could be a promising nutraceutical for preventing and managing hyperuricaemia due to its ability to inhibit XO; this activity is attributed to the combined effect of its phytochemicals and chelating properties.