Pseudomonas aeruginosa is an important opportunistic human pathogen that is found in most communities in Nigeria. One hundred and sixty-five (165) wound swabs specimens were aseptically collected from three hospitals (Specialist Hospital, Maryam Abacha Women and Children Hospital and Noma Children Hospital, Sokoto) and investigated for the possible presence of P. aeruginosa. The swabs were aseptically cultured on MacConkey agar, organisms identified using standard biochemical tests and Muller Hinton agar for sensitivity. A prevalence rate of Pseudomonas aeruginosa isolates amounting to 32(19.4%) was obtained from the wound sites investigated, out of which 14(8.5%) were multi-drug-resistant. Statistically, Chi square analysis showed that there was no significant difference in the number of isolates from SHS, MAWCHS and NCHS and in the occurrence of organism in relation to gender and age (p˃0.05). The incidence of P. aeruginosa was highest (10.9%) at Specialist Hospital, Sokoto, compared with other collection points investigated. Antibiogram studies revealed that P. aeruginosa was most resistant to colistin, aztreonam and ceftazidime to a magnitude of 87.5%, 40.6% and 37.5% respectively, while the organism was most susceptible to imipenem (90.6%) followed by piperacillin-tazobactam (78.1%) and ciprofloxacin (56.3%). Antibiogram becomes very important in clinical cases to forestall possible recrudescence of infection. However, there is need for routine antibiotic sensitivity check.