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Interrogating PR/SET domains for the ability to bind SAH

Name: Interrogating PR/SET domains for the ability to bind SAH
Creator: Ivanochko, Danton
Keywords: Methyltransferase, PRDM, Fluorine nuclear magnetic resonance spectroscopy

Research datakeyboard_double_arrow_right Dataset 06 Nov 2020Publisher:Zenodo

Authors: Ivanochko, Danton;

doi: 10.5281/zenodo.4253144 , 10.5281/zenodo.4253145

Interrogating PR/SET domains for the ability to bind SAH

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Abstract

This is an excerpt from my PhD thesis where I investigated 13 human PR/SET domains from the PRDM protein family and assessed their ability to bind to a fluorinated SAH analog. The research helps to identify which of the PRDMs could be methyltransferases. This work was carried out in the laboratory of Dr. Cheryl Arrowsmith at the University of Toronto and the University Health Network.

Keywords

Methyltransferase, PRDM, Fluorine nuclear magnetic resonance spectroscopy

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