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ZENODO
Dataset . 2017
License: CC BY
Data sources: Datacite
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ZENODO
Dataset . 2017
License: CC BY
Data sources: ZENODO
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ZENODO
Dataset . 2017
License: CC BY
Data sources: Datacite
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ZENODO
Dataset . 2017
License: CC BY
Data sources: ZENODO
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ZENODO
Dataset . 2017
License: CC BY
Data sources: Datacite
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ZENODO
Dataset . 2017
License: CC BY
Data sources: ZENODO
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ZENODO
Dataset . 2017
License: CC BY
Data sources: Datacite
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ZENODO
Dataset . 2017
License: CC BY
Data sources: ZENODO
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ZENODO
Dataset . 2017
License: CC BY
Data sources: Datacite
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Oxford University Research Archive
Dataset . 2018
Data sources: Oxford University Research Archive
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ZENODO
Dataset . 2017
License: CC BY
Data sources: ZENODO
DataBank, Bodleian Libraries, University of Oxford
Dataset . 2018
Data sources: Datacite
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Claim

Human alpha-aminoadipic semialdehyde synthase (AASS); A Target Enabling Package

Research datakeyboard_double_arrow_right Dataset 02 Jun 2017 United Kingdom Publisher:ZenodoFunded by:WT | A UK Hub to Catalyse Open...
Authors: Jola Kopec; Izabella Pena; Elzbieta Rembeza; Mark McLaughlin; Oleg Fedorov; Claire Strain-Damerell; Solenne Goubin; +6 Authors

doi: 10.5281/zenodo.2653517 , 10.5281/zenodo.1287248 , 10.5281/zenodo.4153536 , 10.5281/zenodo.1302967 , 10.5281/zenodo.1219674 , 10.5287/bodleian:9r6aywpgq

Human alpha-aminoadipic semialdehyde synthase (AASS); A Target Enabling Package

Abstract

This work provides the early tools to develop substrate reduction inhibitors for a genetic childhood seizure disorder, with the hypothesis to target the enzyme (AASS) upstream of the defective gene (ALDH7A1) in the human lysine metabolic pathway. This TEP package includes recombinant human AASS purification protocols, structures of the AASS second domain in different states, in vitro assays to detect ligand binding (differential scanning fluorimetry) and enzyme activity (NADH formation) of human AASS, as well as initial chemical matters.

This document represents version 6 of the TEP datasheet and includes all updates on the project as of April 2019. For more information about TEPs and the TEP Programme, please visit https://thesgc.org/tep.

Country
United Kingdom
Related Organizations
Keywords

disease, structure discovery, infectious disease, malaria, chemical probe, chemical biology, structural genomics, metabolic diseases, drug target, drug discovery, neurological genetic disorders, Drug Discovery, Chemical Biology, oncology, target enabling package, cancer, Structural Genomics, neuropsychiatry, neuro, AASS, structure, orphan disease, protein

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download
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
views
OpenAIRE UsageCountsViews provided by UsageCounts
downloads
OpenAIRE UsageCountsDownloads provided by UsageCounts
0
Average
Average
Average
29
13
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