The objective of this study is to find the efficacy of rectal indomethacin in prevention of pancreatitis in Pakistan. This cross sectional study was conducted at Dera Ghazi Khan Teaching Hospital during January 2020 to June 2019. There were 100 patients which were selected for this study. Patients divided into two groups. One group (50 patients) was given per rectal indomethacin while other group (50 patients) given no suppositories. Age distribution of the patients was done, it shows that 30%(n=45) in Indomethacin and 29.33%(n=44) without Indomethacin group were between 15-50 years of age while 70%(n=105) in Indomethacin and 70.67%(n=106) without Indomethacin group were between 51-85 years of age, mean + SD was calculated as 56.28+8.39 and 55.72+7.84 years in both groups respectively. It is concluded that the frequency of Post ERCP Pancreatitis is significantly lower in patients treated with rectal indomethacin when compared to those without it.