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{"references": ["de Lima RMS, Barth B, Arcego DM, et al. Amygdala 5-HTT Gene Network Moderates the Effects of Postnatal Adversity on Attention Problems: Anatomo-Functional Correlation and Epigenetic Changes. Front Neurosci-Switz. 2020;14(198).", "Silveira PP, Pokhvisneva I, Parent C, et al. Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression. Dev Psychopathol. 2017;29(5):1601-1617.", "Miguel PM, Deniz BF, Deckmann I, et al. Prefrontal cortex dysfunction in hypoxic-ischaemic encephalopathy contributes to executive function impairments in rats: Potential contribution for attention-deficit/hyperactivity disorder. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. 2017:1-14.", "Mulligan MK, Mozhui K, Prins P, Williams RW. GeneNetwork: a toolbox for systems genetics. In: Systems Genetics. Springer; 2017:75-120.", "Miller JA, Ding S-L, Sunkin SM, et al. Transcriptional landscape of the prenatal human brain. Nature. 2014;508(7495):199-206.", "Hari Dass SA, McCracken K, Pokhvisneva I, et al. A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions. EBioMedicine. 2019;42:188-202."]}
This pipeline intends to facilitate the calculation of biologically informed polygenic scores from collected genomic data. This template can be adapted to create other expression-based polygenic risk scores. Data is 1) step by step description and 2) a list of genes that compose the gene network.
canadian-open-neuroscience-platform, Expression based Polygenic Risk Score, 5HTT, Amygdala
canadian-open-neuroscience-platform, Expression based Polygenic Risk Score, 5HTT, Amygdala
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| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Average |
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