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Expression-based polygenic score from the amygdala 5HTT gene network

Authors: Merscher Sobreira de Lima, Randriely; Barth, Barbara; Mar Arcego, Danusa; José de Mendonça Filho, Euclides; Clappison, Andrew; Patel, Sachin; Wang, Zihan; +9 Authors

Expression-based polygenic score from the amygdala 5HTT gene network

Abstract

{"references": ["de Lima RMS, Barth B, Arcego DM, et al. Amygdala 5-HTT Gene Network Moderates the Effects of Postnatal Adversity on Attention Problems: Anatomo-Functional Correlation and Epigenetic Changes. Front Neurosci-Switz. 2020;14(198).", "Silveira PP, Pokhvisneva I, Parent C, et al. Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression. Dev Psychopathol. 2017;29(5):1601-1617.", "Miguel PM, Deniz BF, Deckmann I, et al. Prefrontal cortex dysfunction in hypoxic-ischaemic encephalopathy contributes to executive function impairments in rats: Potential contribution for attention-deficit/hyperactivity disorder. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. 2017:1-14.", "Mulligan MK, Mozhui K, Prins P, Williams RW. GeneNetwork: a toolbox for systems genetics. In: Systems Genetics. Springer; 2017:75-120.", "Miller JA, Ding S-L, Sunkin SM, et al. Transcriptional landscape of the prenatal human brain. Nature. 2014;508(7495):199-206.", "Hari Dass SA, McCracken K, Pokhvisneva I, et al. A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions. EBioMedicine. 2019;42:188-202."]}

This pipeline intends to facilitate the calculation of biologically informed polygenic scores from collected genomic data. This template can be adapted to create other expression-based polygenic risk scores. Data is 1) step by step description and 2) a list of genes that compose the gene network.

Keywords

canadian-open-neuroscience-platform, Expression based Polygenic Risk Score, 5HTT, Amygdala

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
views
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