This report will help readers better understand the international, EU and selected countries’ legal developments and approaches to specific legal issues and human rights challenges related to human enhancement. The report broadly discusses the legal issues and human rights challenges of human enhancement. It analyses relevant international, EU and regional laws and human rights standards. It summarises and compares the results of the country studies on law and human enhancement. It also discusses the adequacy of existing norms and standards and gaps and presents some recommendations that will be further developed in the forthcoming SIENNA work.