A prospective study was designed to discuss the spread of hepatitis C virus HCV and the incidence of diabetes mellitus type 2 in addition to other risk factors like donation and receiving blood. Quite a number of patients underwent tattoo operation and among one hundred patients with chronic kidney disease CKD (55 females and 45 males) enrolled in the department of dialysis at Baghdad Teaching Hospital from the period of February to December/2019. All patient underwent blood investigation of HbA1c and Sera were examined by ELISA to investigate HCV antibodies in blood samples patients studied. The results showed that thirty six patients had the infection of hepatitis C virus and thirty five of them were suffering from diabetes mellitus type 2. The results also obtained that (53) of chronic kidney disease patients donated blood before been patients (28 were females and 25 males). 53 of these patients had received blood before (28 females and 25 males) and 10 of these patients had tattoo operation (4males and 6 females). Significant correlation was found between gender of the patients included in this study. We concluded that Chronic Hemodialysis patients commonly exposed to the infection by hepatitis C virus and more frequently had diabetes mellitus type 2. People who had donated or received blood and who also had done tattoo operation or not were also higher in percentage among hemodialysis patients than others.