In this paper, the bit error rate (BER) performance study on video transmission in a V-BLAST encoded 2×2 MIMO MC-CDMA wireless communication system has been made. The system deploys two channel encoding schemes (1/2-rated Convolution and CRC) under four digital modulations (BPSK, DPSK, QPSK and QAM) and zero forcing (ZF) channel detection method. It is apparent that the BPSK modulation outperforms as compared to DPSK, QPSK and QAM modulation schemes in V-BLAST based MIMO MCCDMA communication system under AWGN channel. The 16QAM digital modulation shows worst performance in video transmission as compared to other low order digital modulations. It is obvious from the present MATLAB based simulation study that the V-BLAST encoded 2×2 MIMO MC-CDMA wireless system with the deployment of ZF signal detection and ½-rated Convolution and CRC channel coding schemes shows superior performance using BPSK digital modulation in video transmission.