Carpal Tunnel Syndrome is a common pathological condition that causes pain, numbness and tingling in the hand and arm. The condition occurs when one of the major nerves to the hand, the median nerve is squeezed or compressed as it travels through the carpal tunnel. In most patients, carpal tunnel syndrome gets worse over time, so early diagnosis and treatment are important. If pressure on the median nerve continues, however, it can lead to nerve damage and worsening symptoms. To prevent permanent damage, surgery to take pressure off the median nerve may be recommended for some patients. Ayurveda has an advocated various treatment modalities such as Snēha, Upanāha, Agnikarma and Bandhana. Amongst these, Agnikarma seems to be more effective in providing distinct and instant relief. A 40 year-old-female patient was presented with severe pain, numbness and tingling in the hand once she is doing day to day cooking work and she complained that exacerbation of pain at night for 8 months. On examination, she was diagnosed as she is having carpal tunnel syndrome. After careful examination, patient was treated with Agnikarma without any oral medication. Superficial multiple wounds at the area of carpal flexor tunnel produced by Agnikarma healed within 5-7 days. Patient was advised not to lift any heavy objects and perform any twisting movement for further 6 months. Patient visited for follow-up for 1 month after completion of treatment–Agnikarma. The patient noticed that pain, numbness and tingling in the hand were disappeared. It was concluded that Agnikarma can be recommended as an effectiveness treatment for Carpal Tunnel Syndrome.