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Interferencia inmunológica entre los polisorbatos parenterales y los virus como posible causa de la pandemia por coronavirus

Authors: Elisa M.ª Sahún García; Juan F. Gastón Añaños; Ana Martínez Giménez;

Interferencia inmunológica entre los polisorbatos parenterales y los virus como posible causa de la pandemia por coronavirus

Abstract

Se estudia la posible relación entre la vacunación antigripal de la campaña 2019-2020 y la frecuencia relativa de muertes por COVID-19, encontrándose que la administración de la vacuna antigripal adyuvada podría estar asociada a un riesgo 6 veces mayor de fallecimiento por COVID-19 en mayores de 65 años. Dado que en la composición de esa vacuna se encuentran los polisorbatos, sustancias con antecedentes tóxicos conocidos, se plantea la hipótesis de que la mayor tasa de fallecimientos por COVID-19 podría ser consecuencia de un efecto adverso de los polisorbatos parenterales. Se discute la conocida capacidad de los polisorbatos parenterales de alterar significativamente las membranas celulares como posible causa de una interferencia en la capacidad de las C-lectinas del endotelio vascular de unirse a los virus nuevos como primer paso para su posterior eliminación, con el consiguiente fracaso de la inmunidad innata frente a los coronavirus y la consiguiente facilitación de su infección.

Este trabajo ha sido revisado y actualizado en un nuevo artículo: https://zenodo.org/record/4718467

Keywords

interferencia inmunológica, tormenta de citoquinas, Polisorbato 80, SARS-CoV-2, glicoproteína espiga, C-lectinas, COVID-19, CD209L, vacuna gripe adyuvada, interferencia tóxico-inmunológico-vírica, polisorbatos, L-SIGN

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