EOSC-Life will make LS RIs data resources FAIR and publish them in the EOSC following guidelines and standards (e.g. EDMI). Overall this will drive the evolution of the RI repository infrastructure for EOSC and integration of the LS RI repositories. EOSC-Life will implement workflows that cross disciplines and RI boundaries and address the needs of interdisciplinary science. The goal of the EOSC-Life project is to make sure that life-scientists can find, access and integrate life-science data for analysis and reuse in academic and industrial research. EOSC-Life will transform European lifescience by providing an open, continent-scale, collaborative and interdisciplinary environment for data-driven life science. This requires a knowledge management plan (i.e., data management + knowledge environment management) that covers aspects of the different activities to build up for the platform that cater to the EOSC-Life mission. This document, though titled Data Management Plan, therefore, will also include the aspects of managing software tools, compute cloud architectures, and interoperability of these components as the foundation for the EOSC-Life knowledge environment. Additionally, EOSC-Life data management plan will address the data policies needed for human research data under GDPR. Interoperable provenance information describes the history of sample and data to ensure reproducibility and adherence to regulatory requirements.