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Cardiovascular disease is a top socio-medical problem in all industrialized countries. One of the most important conditions for increasing life expectancy, as well as maintaining viability and quality of life, is to address the issue of proper treatment of cardiovascular disease, as well as their timely prevention. One of the most effective ways to achieve this goal is the timely detection and proper treatment of hypertension. Experts note that in diseases such as stroke, coronary heart disease, including myocardial infarction, heart and renal failure can be reduced their level as a result of adequate antihypertensive therapy. This is especially important in Ukraine, where mortality rates from cardiovascular disease are gaining in importance every year. In recent years, along with the expansion of opportunities in the treatment of hypertension, there has been sufficient information on the effectiveness of drugs that reduce blood pressure. Purpose of our study was to perform a comparative analysis of the prescriptions of different variants of antihypertensive drugs by doctors of Kyiv for 2019. Methods: physician questionnaire and comparative analysis of primary documents (content analysis of medical histories). At the first stage of the study, conducted jointly with the staff of the Institute of Cardiology. A survey of 153 doctors was conducted by the Strazheska Institute of Cardiology of Ukraine (Kyiv), Department of propedeutics of internal diseases No. 1, Department of propedeutics of internal diseases No. 2, Department of internal diseases of the Bogomolets National Medical University (Kyiv). Results: certain patterns of blood pressure lowering were found in patients on the background of hypertension monotherapy, in the treatment of two antihypertensive drugs, and in patients who received two or more drugs.