Supporting Information for Charge Interactions in a Highly Charge-depleted Protein Stefan Hervø-Hansena,b,1, Casper Højgaarda,1, Kristoffer Enøe Johanssona, Yong Wanga, Khadija Wahnic,d,e, David Youngc,d,e,§, Joris Messensc,d,e, Kaare Teiluma, Kresten Lindorff-Larsena**, and Jakob Rahr Winthera* aLinderstrøm-Lang Centre of Protein Science, Department of Biology, University of Copenhagen, DK-2200 Copenhagen N, Denmark, bDivision of Theoretical Chemistry, Department of Chemistry, Lund University, SE 221 00 Lund, Sweden, cVIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie - Vrije Universiteit Brussel, B-1050 Brussels, Belgium, dBrussels Center for Redox Biology, Vrije Universiteit Brussel, B-1050 Brussels, Belgium, eStructural Biology Brussels, Vrije Universiteit Brussel, B-1050 Brussels, Belgium *To whom correspondence may be addressed jrwinther@bio.ku.dk **Co-corresponding author, lindorff@bio.ku.dk 1 These authors contributed equally to this work. Preprint available on BioRXiv