The study examined outcome of educational intervention on knowledge and prevention of compassion fatigue among nurses in Lagos University Teaching Hospital, Nigeria. This study adopted a quasi-experimental one group pre-test and post-test design. The population for this research included registered nurses (RN) who are clinical providers. Total enumeration method was adopted for the study and the sample size was 87 respondents. The Instrument for data collection was a 19 item self-structured questionnaire that elicited information relevant to the objectives of the study. The questionnaire was validated using face and content criteria by experts in the field of nursing and Tests & Measurement who ensured that the questions in the research instrument were relevant to the research objectives. A test re-test was used to ensure reliability of the research instrument which yielded reliability index of 0.821. The experimental procedure was in three phases namely pre-intervention stage, intervention stage and post-intervention stage. Data collected were analysed using descriptive and inferential statistics. The pre and post intervention mean score of the participants on knowledge of compassion fatigue were (2.91±0.97) and (5.09±1.05). The pre and post intervention mean scores on prevention method of compassion fatigue were (11.01±3.28) and (21.97±1.55). There were significant differences between pre and post-intervention level of knowledge (Knowledge gained = 2.18; t = 8.468; p = .000< .05) and prevention (Knowledge gained = 10.96; t = 13.70; p = .000) of compassion fatigue among the nurses. It was recommended among others that an intensive and comprehensive educational initiative should be organized by nursing leaders and tailored to meeting the specific needs of nurses at all levels of nursing. Keywords: Intervention, Knowledge, Prevention, Compassion Fatigue,

This article has been published at www.easij.com , Issue: 1, Volume: 2, July 2020.