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ZENODO
Dataset . 2020
License: CC BY
Data sources: Datacite
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
ZENODO
Dataset . 2020
License: CC BY
Data sources: Datacite
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
ZENODO
Dataset . 2020
License: CC BY
Data sources: ZENODO
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Claim

Transfer learning enables prediction of CYP2D6 haplotype function

Research datakeyboard_double_arrow_right Dataset 18 Jul 2020Publisher:Zenodo
Authors: McInnes, Gregory;

doi: 10.5281/zenodo.3951094 , 10.5281/zenodo.3951095

Transfer learning enables prediction of CYP2D6 haplotype function

Abstract

This data here were used to train the models described in the manuscript "Transfer learning enables prediction of CYP2D6 haplotype function". The deep learning model described predicts metabolic function of CYP2D6 star alleles. It uses two pretraining steps, first with simulated data, then with sequence data collected from liver microsomes, and finally using sequence data for CYP2D6 star alleles. simulated_cyp2d6_diplotypes.tar.gz - This file contains sequence data and labels for simulated CYP2D6 data used in the first training step dalton_2019_cyp2d6_microsomes.txt - This file contains summary statistic data for liver microsome data used in the second pretraining step (originally from https://doi.org/10.1111/cts.12695) star_samples.vcf - This file contains sequence data for CYP2D6 star alleles derived from PharmVar (https://www.pharmvar.org/gene/CYP2D6) used in the final training step.

Related Organizations
Keywords

Pharmacogenetics, CYP2D6

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