In this project, the Ludwig Boltzmann Gesellschaft (LBG) Open Innovation in Science Center invited a multi-stakeholder group consisting of researchers from multiple disciplines, citizen scientists, youth and patient advocates to co-create a guide ‘How to’ meaningfully involve patients and the public in research. In a series of consecutive workshops, the interactions between researchers and the public and patients, e.g. building trustful relationships and communication with patients, and the project steering structures enabling active involvement of patients ant the public in research were discussed. As a result of these workshops, the ‘How to’ Guide for Researchers was co-developed to support the implementation of public and patient involvement (PPIE). It will further inform funding criteria for future PPIE activities and fosters a sustainable and meaningful implementation of involvement activities in research across disciplines.