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image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
ZENODO
Dataset . 2020
License: CC BY
Data sources: Datacite
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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Dataset . 2020
License: CC BY
Data sources: ZENODO
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Dataset . 2020
License: CC BY
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Dataset . 2020
License: CC BY
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Antibody Watch: Text Mining Antibody Specificityfrom the Literature

Authors: Hsu, Chun-Nan; Chang, Chia-Hui; Poopradubsil, Thamolwan; Lo, Amanda; William, Karen A.; Lin, Ko-Wei; Bandrowski, Anita; +3 Authors

Antibody Watch: Text Mining Antibody Specificityfrom the Literature

Abstract

Abstract Motivation Antibodies are widely used experimental reagents to test expression of proteins. However, they might not always provide the intended tests because they do not specifically bind to the target proteins that their providers designed them for, leading to unreliable and irreproducible research results. While many proposals have been developed to deal with the problem of antibody specificity, they may not scale well to deal with the millions of antibodies that have ever been designed and used in research. In this study, we investigate the feasibility of automatically extracting statements about antibody specificity reported in the literature by text mining, and generate reports to alert scientist users of problematic antibodies. Results We developed a deep neural network system called Antibody Watch and tested its performance on a corpus of more than two thousand articles that report uses of antibodies. We leveraged the Research Resource Identifiers (RRID) to precisely identify antibodies mentioned in an input article and the BERT language model to classify if the antibodies are reported as nonspecific, and thus problematic, as well as inferred the coreference to link statements of specificity to the antibodies that the statements referred to. Our evaluation shows that Antibody Watch can accurately perform both classification and linking with F-scores over 0.8, given only thousands of annotated training examples. The result suggests that with more training, Antibody Watch will provide useful reports about antibody specificity to scientists.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
views
OpenAIRE UsageCountsViews provided by UsageCounts
downloads
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0
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22
5