Background: Tuberculosis is the public health disease of Pakistan. Liver is the site of metabolism for most of the anti-tuberculosis drugs and these agents harm the liver, resulting into elevated liver enzymes following inflammation (hepatitis). Isoniazid (INH) is often being used in experimental studies in animal models for induction of liver injury. Objective: To assess the hepatoprotective effects of the Co-enzyme Q-10 in rat model with Isoniazid induced hepatotoxicity. Methodology: A total of 50 Rats of Albino Wistar category were divided in 5 equal groups (A,B,C,D and E) randomly. Group A (control) was kept on normal diet without any intervention whereas group B (experimental negative control) was given INH 100 mg/day for induction of hepatitis. Groups C was administered an oral dose of INH as 100mg+CoQ 100mg/day. The group D rats were given INH 150+ Q-10 100mg/day similarly rats in group E were administered INH 200mg+CoQ 100mg/day. Samples of blood were obtained by scarifying rats at the end of study (1month) LFTs for each group were done, comparing different groups on ANOVA using SPSS 22 version. Results: There was significant difference in serum AST, ALT, LDH, ALP, GGT and bilirubin levels between various animal groups. The p-value was 0.00 for serum ALT, p-value was 0.000 for serum AST levels while for the difference in serum LDH p-value was 0.000, for serum ALP the p-value was 0.000, whereas p-value was 0. 000 for serum gamma GT levels and the p-value was 0.000 for serum bilirubin levels among the various animal groups that was highly significant statistically. Conclusion: Co-enzyme Q-10 improved INH induced changes in liver functions and histology.

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