This research has focused on several unwanted effects of environmental pollution on the riverbank residents of Barishal city corporation. Precisely, this survey-based study has focused on the effects of air, water, soil, and noise pollution on human life of riverbank inhabitants. Sixty-three respondents were chosen from nine wards of the riverbank areas for interview using a purposive sampling method. The analyzed data indicated that environmental pollution has severe effects on human life. The result shows these pollutions intensify several diseases such as physical and mental disorders, eye inflammation, noses, and throat irritation, soreness of the respiratory tract, asthma, cancer and chronic pulmonary diseases in this area. Besides, the waste and pollutants in this riverbank area causing fatal ecological destruction, migration of people, change of landscape, and such pollution also creating a threat to global warming and ozone layer depletion. The haphazard management of waste disposal systems, cement industries, chemical industries, shops, markets in this area, and urban waste wreak havoc in this area. Because of the cripple destruction nature, city corporation authorities are not yet concerned about the destructive forces and future threat of environmental degradation. The findings of this research will give some essential grounds to take into account for policymakers and stakeholders for making an effective future action plan.