Within the first fifty days of the epidemic outbreak of novel corona virus in Wuhan, had killed more than eighteen hundred and infected over seventy thousand individuals. All the studies have reported that it is thought to be a member of the β group of corona viruses. The novel virus was named as Wuhan corona virus or 2019 novel corona virus (2019-nCov) by the Chinese researchers because the epidemic began in Wuhan. The International Committee on Taxonomy of Viruses (ICTV) named the virus as SARS-CoV-2 and the disease as COVID-19. In the history, SARS-CoV (2003) infected 8098 individuals with a mortality rate of 9%, across 26 countries in the world on the other hand, novel corona virus (2019) infected 120,000 individuals with mortality rate of 2.9%, across 109 countries, till date. It shows that the transmission rate of SARS-CoV-2 is higher than SARS-CoV and the reason could be genetic recombination event at S protein in the RBD region of SARS-CoV-2 may have enhanced its transmission ability. As a part of the study, we would like to highlight the comparison between SARS-CoV and SARS- CoV -2 along with their drug mechanism and their vaccine studies that came into existence till date.