Mukhadushika is explained by Sushruta under Kushudra rogas. It is characterized by Shalmali Kantka sadrush Pidaka on face. It co-relates to acne vulgaris explained in modern science. These acnes when not treated in the earlier stage leads to severity and hence leave a permanent scar, which mentally depresses individual and face in secure. Hence there is a need to counter this condition effectively and prevent its progress to severity and thereby preventing the eruption of new lesions. In the treatment of Mukhadushika, Vaghbhata, Sharandhara, Chakradutta, Yogaratnakar and Ashtang Hrudhya has mentioned Lodhradhi lepa and Shalmali kantaka lepa in the management of Mukhadushika. But comparison between these drugs doesnt evaluate in the management of Mukhadushika so that this drugs was selected for project work.