Background: The performance of midwives in antenatal care services is carried out in accordance with the service standards in the MCH program set and various factors that influence the performance of midwives are age, employee status, years of service, knowledge, attitudes, motivation, manager skills (coordinating midwives) and facilities. Objective: To find out the factors related to the performance of midwives in the KIA antenatal care program at Ransiki Health Center, South Manokwari Regency, West Papua Province. Research Method: Analytical with cross sectional study design. The population was all midwives in Ransiki Health Center and a sample of 46 people (total poulias. Data were obtained using questionnaires and analyzed using chi square test and logistic binary regression. Results: Factors related to the performance of midwives in ANC services for MCH programs at Ransiki Public Health Center were age (p-value 0.002; RP = 2.697; CI95% = 1.262 - 5.763), employee status (p-value 0.001; RP = 7.333; CI95 % = 2,821; CI95% 1,416 - 5,619), working period (p-value 0,000; RP = 3,864; CI95% (1,782 - 8,377), attitudes (p-value 0,016; RP = 1,895; CI95% (1,191 - 3,015), motivation (p-value 0,000; RP = 2,750; CI95% (1,464 - 5,164), facilities (p-value 0,015; RP = 1,833; CI95% 1,258 - 2,673) and reward (p-value 0,008; RP = 2,009; CI95% (1,237 – 3,264), While factors not related to the performance of midwives in KIA ANC program services in Ransiki Public Health Center is knowledge (p-value 0.717; RP = 1,200; CI95% (0,735 - 1,960) and manager skills (p-value 1,000; Rp = 1,083; CI95% (0,667 - 1,757). Dominant factors related to performance midwives in ANC services in the mother and child program is motivation (p value= 0,001; OR = 16,713; CI= 95%= 3,254-85,846) and facility (p value= 0,034; OR = 13,153; CI= 95%= 1,217-142,213).