Methicillin-resistant Staphylococcus aureus (MRSA) becomes along decades one of the main organisms affecting the health cares area. Thus, the present study was conducted with aims of determining the resistance phenotype of the methicillin-resistant germ, to identify the type of sampling, and to locate hospital departments that are mostly exposed to risks. A retrospective, a descriptional study was conducted at the laboratory of the microbiology of the UHC Professeur Zafisaona Gabriel (PZaGa) for five years from January 2013 to December 2017. In whole, 97 samples with Staphylococcus aureus were included, and 47% (n=46) of which were resistant to methicillin. Patients aged from 28 to 38 years were severely hit by methicillin-resistant Staphylococcus aureus, which was 28,26% (n=13). No significant predominance was related to gender. The sex-ratio was of 1,08 (p>0.05). Hospitalized patients and those from outward care were respectively 59% and 41%. The Surgery Department and Reanimation Unit were mostly affected, with respectively 63% and 15%. Suppuration sampling was the most exposed, which was 30% (n=29) among which wounds from chronic suppurative sores and diabetic patients were common, respectively, with 11% and 10%. This study showed results with a high rate of MRSA. It represents half of the strains.