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ZENODO
Dataset . 2020
License: CC BY
Data sources: Datacite
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ZENODO
Dataset . 2020
License: CC BY
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ZENODO
Dataset . 2020
License: CC BY
Data sources: ZENODO
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CCLid: A toolkit to authenticate the genotype and stability of cancer cell lines

Authors: Rene Quevedo; Benjamin Haibe-Kains; Trevor J Pugh;

CCLid: A toolkit to authenticate the genotype and stability of cancer cell lines

Abstract

CCLid (Cancer Cell Line identification) is designed as a toolkit to address the lack of a publicly available resource for genotype-based cell line authentication. We developed this resource to allow for genotype-matching of any given cancer cell line to the 1,204 unique cell lines found in the CCLE dataset, with support to include additional SNP array datasets. Using the B-allele frequencies (BAFs) for all SNPs found in common between the input data and reference datasets, this tool will allow for a genotype matching operation that trains and uses a logistic model to calculate the probability of the best cell line matches. This is followed by a measure of genetic drift between isogenic lines by look for segments of the genome that have significantly different BAF values. This zenodo dataset contains the (sample x probeset) BAF matrix for the CCLE dataset, as well as supporting datasets to allow mapping of SNP probesets and genotype correction between SNP array technologies (i.e. Affymetrix SNP 6.0 and Illumina HumanOmni 2.5M). This also contains all the metadata for cell line identities in CCLE, GDSC, and gCSI as well their corresponding cellosaurus unique identifies.

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Keywords

cancer cell lines, genotyping, bioinformatics, genetic drift, cell line authentication

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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Cancer Research