This review focus on the prescribing pattern of drugs and role of diet impact on the management of physiological changes occurs during the pregnancy, and some drugs are fetotoxic (e.g. Methotrexate, Thalidomide, Aspirin, Warfarin etc.) these are not prescribed during pregnancy, if there is individuals suffered with any physiological changes during pregnancy ,drug of selection must be based on pregnancy categories, During pregnancy causes changes in the normal reference ranges for several hormones, electrolytes and other analytes, drug selection should be appropriate and should not harm to the mother and foetus, manage the gestational Hypertension, Diabetes, Hypothyroidism by following proper guidelines, In pregnancy nutritional requirements are increased because of baby growth, iron, calcium, folic acid ,vitamins rich food helpful to healthy pregnancy