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UŞAQLIQ BOYNU DİSPLAZİYALARINDA PD-L1 ÇALIŞMALARIN PROQNOSTİK ƏHƏMİYYƏTİ

Authors: İradə Soltanova; Nigar Mehdiyeva;

UŞAQLIQ BOYNU DİSPLAZİYALARINDA PD-L1 ÇALIŞMALARIN PROQNOSTİK ƏHƏMİYYƏTİ

Abstract

The article is included the clinical and morphological features of 35 patients who had been diagnosed and treated with cervical dysplasia and reflected the immununistochemical results of PD-L1 expression in atypical cells. By standardized immunochemical methods, receptor levels vary depending on the degree of intraepitelial dysplasia. In patients with CIN I, cells were not stained at all (negative PD-L1 reaction), PD-L1 expression in CIN II was 1+ and 2+ in 76.9±5.6% , and 3+ in 23.1±5.3% of patients (p<0.05). In patients with CIN III, 3+ cases (severe staining) were detected in 66.7±4.2% and cases of 2+ (moderate staining) in 33.3±4.9% of women. Thus, expression of the PD-L1 receptor, known as anti tumor immunitite regulator is closely related to dysplastic processes that begin in the tissue. By other words, the detection this receptor expression in patients with CIN diagnosis(especially CIN III) can play an important role in the selection of treatment tactics and assessment of prognosis.

Keywords

clinical and morphological features, cervical dysplasia and reflected the immununistochemical results.

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selected citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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