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Article . 2020
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Claim

3α-Hydroxy-7(E)-ethylidene-5β-cholan-24-oic acid is the highly potent steroidal dual G-protein bile acid receptor 1 (GPBAR1) agonist/farnesoid X receptor (FXR) antagonist

descriptionPublicationkeyboard_double_arrow_right Article 17 Jun 2020 English Publisher:Zenodo
Authors: Kaspar, Miroslav; Stefela, Alzbeta; Drastik, Martin; Kronenberger, Thales; Micuda, Stanislav; Dracinsky, Maring; Klepetarova, Blanka; +2 Authors

doi: 10.5281/zenodo.3898392 , 10.5281/zenodo.3898391

3α-Hydroxy-7(E)-ethylidene-5β-cholan-24-oic acid is the highly potent steroidal dual G-protein bile acid receptor 1 (GPBAR1) agonist/farnesoid X receptor (FXR) antagonist

Abstract

Those files comprise trajectories of MD simulations of FXR monomers in presence of ligands of interest. Methods and ligand specifications are provided in the respective manuscript. Trajectories were generated in Desmond and are provided in this format, alternative formats or specific frames are available upon request.

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Keywords

steroid, G protein-coupled bile acid receptor 1, farnesoid x receptor, Bile acids

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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