Introduction: Guided FNAC of Intra-abdominal and Intra-thoracic mass lesions is a cheap, safe and rapid diagnostic modality used in the cytological evaluation of benign as well as malignant deep seated lesions. Material and Methods: Ours is a retrospective study done in the cytology section of the Department of Pathology Govt. Medical College Jammu over a period of one year from Jan 2019 to Jan 2020. The study included 34 (62.96%) intra-abdominal and 20 (37.04%) intra-thoracic lesions. Results: A total of 54 lesions were studied including 34 (62.96%) intra-abdominal and 20 (37.04%) intra-thoracic. Among intra-abdominal lesions maximum 31 (91.17%) were US Guided FNAC from hepatobiliary mass lesions followed by 1 (2.94%) each from ovary, pancreas and retroperitoneum. All the intra-thoracic lesions were CT guided with maximum 16 (80%) from lungs and 4 (20%) from mediastinum. Malignant lesions 44 cases (81.48%) outnumber the benign lesions 10 cases (18.51%). Conclusion: Image guided FNAC of deep seated lesions can improve the diagnostic yield and a definite diagnosis can be reached in most of the cases.