Introduction: Tumor stroma plays a key role in modulating tumour invasion and metastasis in carcinoma breast. Matrix metalloproteinase CD10 may cause more invasiveness by facilitating matrix degradation and remodelling. Many studies showed higher expression of this marker in higher grade tumours and in tumours with lymph node metastasis. Objectives: a) To study the expression of stromal CD10 in invasive breast carcinomas b)To assess prognostic significance of Stromal CD10 expression and its correlation with clinicopathological features Materials and Method: Stromal expression of CD10 studied in 96 mastectomy specimens andthe association with clinicopathological features evaluated using the chi-square test. P value <0.05 was considered statistically significant. Observations: CD10 scoring was increased in high grade tumours which is statistically significant with(p value 0.017). No significant association could be established statistically for age, menopausal status, tumour size and lymph node status.