Pain in the newborn period puts the individual at risk of developing short- and long-term negative consequences. To provide sufficient prevention and treatment of pain is a cornerstone of neonatal care. This should be done with a multimodal approach, using non-pharmacological and pharmacological interventions. Many of the supportive, non-pharmacological interventions can be delivered by the parents of the newborn infant. The objectives of this study are to: Explore, synthesize and identify possible research gaps in the evidence for the effectiveness of parent-driven pain and stress relieving interventions in neonatal care, Describe parental experiences of delivering pain and stress relief to their newborn infant Investigate and summarize recommendations in national and international guidelines