The spike glycoprotein of SARS-CoV 2 is 3849 bp length present from 21536 to 25384 location in genome as per the prediction from FGENESV0 server and is related to mutated SARS genome. The tiny molecular key on SARS-CoV-2 that gives the virus entry into the cell is called a spike protein, or S-protein. The docking results have shown that compounds like Curcumin (Enol form) and Anti-Viral drugs like Ombitasvir with SARS CoV2 has shown best results. Apart with these compounds Curcumin (Keto form), Cholecalciferol (Vitamin D), Ascorbic acid (Vitamin C), 3-isobutyl-1-methylxanthine (in tea), Chloroquine, Eugenol, Theophylline and Caffeine are also shown better results. The compounds provide support for the development of immune system and control SARS-CoV2. The results have shown that turmeric powder, tea and sun light can treat COVID-2019 in natural way.