The field of nanotechnology is one of the most active areas of research in modern material science. Nanoparticles exhibit completely new or improved properties based on specific characteristics such as size, distribution and morphology.Herbal medicine is still the main stay of about 75-80% of the whole population, and the major part of traditional therapy involves the use of plant extract and their active constituents.New applications of nanoparticles and nano-materials are emerging rapidly. Silver is a well-known antimicrobial agent against a wide range of over 650 microorganisms from different classes such as gram-negative and gram-positive bacteria, fungi or viruses.More recently the metal is finding use in the form of silver nanoparticles. Silver nanoparticles are one of the metal nanoparticles have received significant consideration because they are effective antimicrobial agent/s that exhibits low toxicity. The aim of present study is to synthesize silver nanoparticles by using various extract, characterization of these silver nanoparticles & Converts its gel formulation as well as to observe the antimicrobial activity.