The objective of this study is a comparative analysis of the changes observed on the red blood cell antigens which differ in a short glycoprotein chain difference, by the effects of a Camellia sinensisand Camellia assamica extracts. The heamatological effect of the extract was prepared and evaluated using blood group analysis on haematological indices.Agglutination was clearly observed initially for 5 min for all the eight blood types. Specifically, for the O+ blood group there is a time lag for agglutination to take place for the incubation period of 15 min for C. sinensis, while agglutination occurred after 10 minutes of adding blood group antibodies with C. assamica. These results, as well as the possibility of adapting this method to a fully automated system, could be an important contribution to the field of immunohematology.