Background: Current CoVID-19 is a thretening across the Globe.Till now,there is no specific treatment has been proven to be effective for SARS-CoV-2 infection. Patients were managed with supportive care, such as oxygen supply in mild cases and extracorporeal membrane oxygenation for the critically ill patients, specific drugs for this disease are still being researched. In this scenario Hydroxychloroquine is Effective for anti-inflammatory agent and also Anti-Viral properties, has been used in COVID-19 Patients.It is showing better clinical outcomes in combination with Azithromycin. But Clinical Monitoring is required for this drug which has been discussed in this article. Objective: To know the mechanism of action of hydroxychloroquine in COVID-19. To asses the risk and benefits of hydroxychloroquine therapy in terms of contraindication and adverse effects. Conclusion: Hydroxychloroquine have Anti-Viral Properties that has been used extensively in CoVID-19 and can significantly inhibits the binding of Virion with ACE and decrease the production of cytokines in COVID-19 patients. Although Hydroxychloroquine providing Positive Clinical Outcomes, we must still consider its Contraindications and Adverse effects.