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Claim

ToxicoDB: an integrated database to mine and visualize large-scale toxicogenomic datasets (drug matrix dataset)

Research datakeyboard_double_arrow_right Dataset 16 Mar 2020Publisher:Zenodo
Authors: Kadambat Nair, Sisira; Eeles, Christopher; Ho, Chantal; Beri, Gangesh; Yoo, Esther; Tkachuk, Denis; Tang, Amy; +5 Authors

doi: 10.5281/zenodo.3946407 , 10.5281/zenodo.3766569 , 10.5281/zenodo.3712246 , 10.5281/zenodo.3712247

ToxicoDB: an integrated database to mine and visualize large-scale toxicogenomic datasets (drug matrix dataset)

Abstract

This data was generated by Ganter B, Snyder RD, Halbert DN, Lee MD. Toxicogenomics in drug discovery and development: mechanistic analysis of compound/class-dependent effects using the DrugMatrix database. Pharmacogenomics [Internet]. 2006 Oct;7(7):1025–1044. Available from: http://dx.doi.org/10.2217/14622416.7.7.1025 PMID: 17054413. The data have been curated and analyzed using our open-source R package, ToxicoGx (cran.r-project.org/web/packages/ToxicoGx) and are available publicly in the ToxicoDB web application (www.toxicodb.ca).

- Converted the expressionSet object to SummarizedExperiment - Converted the dataset structure to match the updated version of ToxicoGx currently being submitted to Bioconductor - Updated drug annotations in the dataset to use the most recent PubChem names - The ToxicoGx package is being transitioned from CRAN to Biocondcutor, to access the package please run `BiocManager::install("ToxicoGx")` in your R terminal - URL of the package in Bioconductor : http://bioconductor.org/packages/devel/bioc/html/ToxicoGx.html

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Keywords

Drug Matrix, Toxicogenomics, Open TGGATEs

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selected citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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