The giant retroperitoneal liposarcoma is a relatively rare malignancy, characterized by slow and asymptomatic growth. Because of the anatomical spaces of the retroperitoneum, they often reach giant sizes. It is diagnosed by computed tomography and magnetic resonance imaging. Surgical treatment is the method of choice. We present a clinical case of retroperitoneal liposarcoma in a patient 69 years of age, measuring 35/24/16 cm and weight of 9.5 kg. Surgery includes tumor resection and right hemicolectomy in June 2014 (06/2014) as well as two other operations in the coming years performed by us due to local recurrence. Chemotherapy and radiotherapy have been administered. Chemotherapy and radiotherapy have controversial value according to different authors after the literature review has been made. Publications in Bulgarian and foreign literature in recent years are discussed.