The study investigated the effect of oil value variations and cost-effectiveness towards wealth creation of oil and gas vending corporations. The main objective of the study was to determine whether oil value variation impact on cost-effectiveness in the processes of wealth creation in oil and gas vending corporations in Nigeria. Data were obtained from secondary sources such as annual financial reports of corporations which were within the coverage years of investigation. Simple regression technique was used to analyze the data collected. The findings revealed that, oil value variations do not significantly affect cost-effectiveness in the processes of wealth creation of oil and gas vending corporations under consideration. Based on the findings, the study recommended that the management of companies should devise effective strategies in regulating and controlling the effect of oil value variations on their corporate cost-effectiveness towards wealth creation. JEL: L20; L22; L72