descriptionPublicationkeyboard_double_arrow_right Article 23 Sep 2020 English Publisher:Informa UK LimitedJournal:Expert Review of Hematology, volume 13, pages 1,277-1,287 (issn: 1747-4086, eissn: 1747-4094,

Authors: Emrah Yucesan; Ozden Hatirnaz Ng; Fevzi Firat Yalniz; Hulya Yilmaz; Ayse Salihoglu; Tugce Sudutan; Ahmet Emre Eskazan; +6 Authors

doi: 10.1080/17474086.2020.1819786 , 10.5281/zenodo.3730440 , 10.5281/zenodo.3730441

pmid: 32885695

handle: 11443/2196

Copy-number variations in adult patients with chronic immune thrombocytopenia

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Abstract

In this report we identified CNV regions unique to adult ITP patients. Despite several studies the genetic background of ITP is still unclear. There are studies on pediatric cases, describing several genes associated with the disease, but the data is still limited. Here, we aimed to identify regions that may play a role in the pathogenesis of adult ITP by SNP array technology. Our findings support the idea that ITP is not only clinically but also genetically heterogeneous and genetic modifiers play an important role in the development of the disease. We believe that this data will provide important bases for the future studies to enlighten ITP pathogenesis.

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Keywords

Adult, Male, DNA Copy Number Variations, Receptors, Antigen, T-Cell, alpha-beta, Drug Resistance, Whole-genome genotyping, clonality, Gene Rearrangement, T-Lymphocyte, Real-Time Polymerase Chain Reaction, Immune thrombocytopenia, copy number variation, SNP Array, single nucleotide polymorphism, Adrenal Cortex Hormones, Humans, whole-genome genotyping, Genetic Association Studies, Aged, Aged, 80 and over, Purpura, Thrombocytopenic, Idiopathic, Mosaicism, Receptors, Antigen, T-Cell, gamma-delta, Middle Aged, Single nucleotide polymorphism, Immune thrombocytopenia, Clone Cells, Copy-number variation, copy-number variation, Case-Control Studies, Chronic Disease, Female, Clonality

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Copy-number variations in adult patients with chronic immune thrombocytopenia
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Copy-number variations in adult patients with chronic immune thrombocytopenia
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