Statins severely limit hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase, subsequent in decreased plasma aggregate and little lipoprotein thickness cholesterol. Statins have freshly been revealed to have an extra pleiotropic impact by swelling levels of aquaporin 2 channel articulation. AQP2 is largely limited in the kidney and plays a fundamental part in defining the water content of cells. This added impact is free of cholesterol homeostasis, in addition is based on the depletion of mevalonate-determined intermediates of sterol pathways, such as farnesyl pyrophosphate and geranyl pyrophosphate. Our current research was conducted at Mayo Hospital, Lahore Pakistan from March 2018 to February 2019. By increasing PQA2 joint levels, statins increase the reabsorption of water by the kidneys, thus opening another avenue in the treatment of cases through nephrogenic diabetes insipidus, an innate disease that requires powerful and limited treatment of reactions. We talk about angles identified with the water balance dictated by PQA2 in kidney, just as we talk about normal and novel methodologies for NDI restoration. Keywords: apical membrane _ aquaporin _ cholesterol-lowering drugs _ hypercholesterolemia_ HMG-CoA _ kidney _ nephrogenic diabetes insipidus.