Breast cancer (BC) is the most common cancer in female population. Triple-negative breast cancer (TNBC) is the subtype of breast cancer in which the three major receptors are absent. TNBC has very aggressive phenotype and high spreading rate/metastasis which often results in resistance to chemotherapy. Nano-medicines offer various promising approaches to BC and TNBC therapy because of its unique characteristics viz.nanometric size, high drug payload, targeting capabilities and capability to accommodate multiple therapeutic moieties.This review focuses on the conventional therapies, novel approaches and recent treatment strategies available for the therapeutic benefits to the patients. The role of cancer stem cell in the recurrence of BC and TNBC has also been highlighted. Moreover, the application of nanomedicines for the treatment of BC/TNBC and different molecular targets available for further exploration have also been discussed.Nanomedicines offers a right platform to develop multi-faceted treatment strategies to control the spread and recurrence of BC/TNBC. Researchers explored multiple pathways that can play a major role in controlling the progression of TNBC. Several chemotherapeutic agents were delivered using these nanocarriers with outstanding responses. Numerous targets were also reported that could stop/alter the specific pathway or receptor interaction.